|
KMID : 1202020140070020118
|
|
Journal of Korean Thyroid Association
2014 Volume.7 No. 2 p.118 ~ p.128
|
|
|
Gene Methylation Associated with Differentiated ThyroidCancer
|
|
Tae Soon-Young
Chi Hyun-Keun
Kim Su-Jin
Lee Kyu-Eun
Youn Yeo-Kyu
|
|
|
Abstract
|
|
|
|
Epigenetic alteration changes expression of many genes, such as tumor suppressor gene and molecular specificgene, without change in DNA sequence. Cancers, including thyroid cancer, often exhibit an aberrant methylationof gene promoter regions, which is associated with loss of gene function. Aberrant methylation plays afundamental role in tumorigenesis. Methylation of some genes tends to occur in certain types of thyroid cancer.Methylation of TIMP3, SLC5A8, p16, RARβ2, DAPK genes is associated with papillary thyroid cancer. Some studiesshow that aberrant methylation is related to the BRAF V600E mutation. Methylation of PTEN and RASSF1A genesoccurs commonly in follicular thyroid cancer. Methylation of thyroid-specific genes, such as sodium/iodidesymporter, thyroid-stimulating hormone receptor, and SLC26A4 which encodes pendrine, also has a relation tothyroid cancer. Methylation of these genes could be utilized as markers to detect early disease, to defineprognosis and to predict therapeutic targets of thyroid cancer.
|
|
|
KEYWORD
|
|
|
Epigenetics, Methylation, Thyroid cancer, Genes, Tumor suppressor
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|
|